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Dutas prevents the conversion of testosterone to dihydrotestosterone (DHT) in the body. DHT is involved in the development of benign prostatic hyperplasia (BPH).

Dutasteride generic available in the U.S. is now available in Canada under the brand name dutasteride 0.5% tablet. The tablet is supplied by Dutasteride Inc. on behalf of the U.S. market through its marketing authorized dealer in Canada. The tablet is available in U.S. with an initial monthly dose of 10 mg, and may be dispensed in multiples of 10, 20 or 30 mg, depending on the type of patient. In U.S., for example, Dutasteride has a recommended dose range of 5 to 10 mg/day. Preliminary results on a Phase III study of men with low-volume prostate cancer have shown that Dutasteride, at doses of up to 150 mg daily, could extend median survival by at least one month compared to placebo. Dutasteride also has a shorter latency period in prostate cancers than do testosterone esters like flutamide for this reason. The active ingredient in dutasteride is testosterone enanthate. It also available as a generic form, dutasteride 1 mg/ml tablet (DUT), available in Europe. It is also available as part of Dutasteride's Prostate Cancer Management Protocol (PPC) including DUT, Dutasteride (Nanotex, Inc. San Diego, CA, USA), and Prostatic Cancer Pharmacotherapy: A Protocol for Use With Dutasteride. Dutasteride Pharmacokinetics — In patients with hypogonadism, the serum total T level rises within 14 days of starting dutasteride and then remains elevated for 3 weeks. However, serum total T levels then fall after about 14 days of dutasteride cessation. Following discontinuation of therapy, total T levels are stable (at a baseline level of about 50%) for up to 14 weeks. Thus, it is not known whether the lower incidence of symptomatic prostate cancer seen in these studies is attributable to a sustained decrease in serum total T or to a delay in the time it takes for body to clear free-base testosterone after DUT discontinuation. The primary mechanism by which Dutasteride reduces serum total T is by acting upon its binding affinity for the sex-hormone receptor type (SR) B and/or its binding affinity for the androgen receptor (AR). This binding, via Dutas 0.5mg $228.34 - $1.9 Per pill both the SR and AR, promotes generic dutasteride price its metabolism by cytochrome P450 enzymes to the inactive form of androgens (T) which are excreted in urine by the kidney. active form of testosterone is then excreted via the kidneys by renin-angiotensin-aldosterone system as dihydrotestosterone. The lower incidence of prostate disease observed in Finpecia for sale male patients receiving DUT has.

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